In bladder cancer, human epidermal growth factor receptor 2 (HER2) overexpression is strongly linked with tumor progression and poor prognosis, although HER2 genomic amplification is not a typical mechanism (Chow et al., 2001; Jimenez et al., 2001; Kruger et al., 2002; Fleischmann et al., 2011). The gene discussed is ERBB2; the disease is urinary bladder cancer.