Many biomarkers of PCa have been developed successively, such as Prostate Health Index (PHI), prostate cancer antigen 3 (PCA3), four-kallikrein panel (4K), transmembrane protease serine 2-ERG (TMPRSS2-ERG), ExoDx Prostate Intelliscore and SelectMDx (5, 6). The gene discussed is PCA3; the disease is posterior cortical atrophy.