Subsequent to the adjustment of the multivariate regression model for age, sex, DBP, SBP, educational level, current drinker, duration of diabetes, hypertension, FPG, HbA1c, leukocytes, ALB, and hs-CRP, higher OR values for DKD were found in the third LAPI tertile than in the first LAPI tertile (P < 0.001), and the OR (95% CI) for DKD was 2.135 (1.438–3.171) in the third tertile of LAPI compared to that in the first tertile. The gene discussed is CRP; the disease is diabetic kidney disease.