GBP1 and neoplasm: Intracellular expression of GBP-1 inhibits angiogenesis in endothelial cells (Guenzi et al., 2001), and inhibits proliferation and migration in tumor cells and intestinal epithelial cells, while preventing cell apoptosis (Schnoor et al., 2009; Britzen-Laurent et al., 2013; Ostler et al., 2014).