In murine colitis models, inhibition of CXCL10 reduces intestinal inflammation (Sasaki et al., 2002; Singh et al., 2003; Hyun et al., 2005; Suzuki et al., 2007; Zhao et al., 2017) but also had unexpected effects on intestinal epithelial cells (Sasaki et al., 2002; Singh et al., 2003; Hyun et al., 2005; Suzuki et al., 2007; Zhao et al., 2017). Here, CXCL10 is linked to colitis.