This is supported by the fact that, the knock-out of IL-18 in endothelial cells, hematopoietic cells or in intestinal epithelial cells was found to abrogate DSS-induced colitis, while the knock-out of IL-18R was only protective when present in intestinal epithelial cells (Nowarski et al., 2015). The gene discussed is IL18R1; the disease is colitis.