Higher IL-18 and IL-18BP levels have also been observed in the serum of IBD patients as compared to controls, which might be attributed to secretion by endothelial cells (Corbaz et al., 2002; Ludwiczek et al., 2005; Naftali et al., 2007; Leach et al., 2008). The gene discussed is IL18BP; the disease is inflammatory bowel disease.