VWF and inflammatory bowel disease: This approach yielded six putative candidates that are secreted from endothelial cells and may contribute to IBD pathogenesis, including proteins of the von Willebrand factor domain superfamily (VWA1, vWF), tissue inhibitor of metalloproteinases (TIMP)-1, matrix metalloproteinase (MMP)-14, the chemokine CXCL10, and the matricellular protein SPARCL1 (Stürzl et al., 2021).