Sarkar et al. (2015) validated the correlation between the RARβ2 gene and tumor progression regarding chromatin activation. More than 70% of cancers show inactivated RAR 2 gene function. In melanoma, RARβ2 silencing is due to hypoacetylation of the gene rather than hypermethylation. CpG island methylation of RARβ led to the methylation of this gene, causing subsequent non-functionality in cervical cancer patients (Wongwarangkana et al., 2018). This evidence concerns the gene RARB and cancer.