ACE2 and viral infectious disease: For example, T-cell immunoglobulin and mucin domain 1 (TIM-1) and TIM-4, as important phosphatidylserine (PS) receptors in the TIM and TAM families, can directly interact with PS on the outer leaflet of SARS-CoV-2, enhancing viral infection by promoting ACE2-dependent SARS-CoV-2 endocytosis fusion (Bohan et al., 2021).