POMC and major depressive disorder: We believe that it is necessary to implement medical and psychological control tests for all doctors in health institutions, as well as to evaluate other variables, such as the quality of diet, the adaptive response, the serum levels of the adrenocorticotrophic hormone (ACTH), and lifestyle factors to be able to make an intervention in a timely manner and reduce the risk of suicide and depression symptoms, which have a high cost for individuals and institutions.