When the cut-off value of sST2 is 63.02 pg/ml, it showed the best predictive value in predicting all-cause mortality in HFpEF patients (sensitivity 58.82%, specificity 81.77%) [46]; and its predictive ability to assess all-cause mortality, HFR, or worsening renal function in HF patients is superior to NT-proBNP [61]. Here, NPPB is linked to hydrops fetalis.