Genetically predicted levels of crude SHBG may increase the risk of RA overall (IVW OR = 1.18, 95% CI = 0.99–1.41), but this trend was not observed either in men (IVW OR = 1.03, 95% CI = 0.86–1.22) or women (IVW OR = 1.10, 95% CI = 0.91–1.32). The gene discussed is SHBG; the disease is rheumatoid arthritis.