SHBG and rheumatoid arthritis: For example, a small-sized case–control study (55 RA and 50 controls) reported SHBG levels to be significantly lower in female cases than in controls, both pre-menopausal (34.8 ± 10.0 vs. 58.4 ± 17.9 nmol/L) and post-menopausal (35.5 ± 10.7 vs. 44.9 ± 7.1 nmol/L) [7], while another case–control study (120 RA and 518 controls) did not support such a difference (post-menopausal: 57.6 ± 26.9 vs. 57.3 ± 27.3 nmol/L) [6].