SNN, a protein-coding gene playing a role in the toxic effects of organotin [45] and endosomal maturation [46], has been proved to be linked to SHBG [11] and a number of other autoimmune diseases [47] including ankylosing spondylitis, psoriasis, ulcerative colitis, Crohn’s disease, and sclerosing cholangitis. The gene discussed is SHBG; the disease is sclerosing cholangitis.