Genetic analysis revealed the presence of two heterozygote variants (c.598G > A, p. Val200Me) in NLRP3 gene, consistent with a diagnosis of Cryopyrin-associated Periodic Syndrome (CAPS), and was started on Colchicine that has normalized her blood eosinophil count. The gene discussed is NLRP3; the disease is cryopyrin-associated periodic syndrome.