Lp(a) is an atherogenic lipoprotein composed of an LDL–like moiety with one plasminogen-like apolipoprotein-A covalently bound to apolipoprotein B. Circulating levels of Lp(a) are primarily determined by hereditary modifications at the LPA gene locus, leading to its association with familial hyperlipidemia [31]. The gene discussed is PLG; the disease is familial hyperlipidemia.