CYP2R1 and colorectal cancer: The methylation status of the CYP2R1 at all CpG sites was inversely associated with colorectal cancer risk, with an adjusted OR (aOR) of 0.49 (95% CI, 0.26–0.91; P = 0.02) comparing the hypermethylation with hypomethylation of the CYP2R1 gene.