PPARG and diabetes mellitus: Moreover, 16 weeks of CLA supplementation (8 g oil/d contain 6.4 g/d net CLA without isomers identified) in obese women with diabetes reduced BMI and total adipose mass, but had no effect on lean body mass [78], which could potentially be due to the effect of CLA on PPAR-γ, as CLA is modest ligand for PPAR-γ [79].