PTCSC3 and thyroid gland undifferentiated (anaplastic) carcinoma: Another function of PTCSC3 in TC cells is to reduce drug resistance; PTCSC3 overexpression could decrease doxorubicin resistance in anaplastic thyroid cancer (ATC) cells by downregulating the oncogenic transcription factor, signal transducer and activator of transcription3 (STAT3).