Survival analyses of model gene expression and methylation levels showed that CFTR and PKIA were associated with survival in patients with LUAD (Fig. 4A-D).In order to manage the clinical prognosis of lung cancer patients and provide clinicians with a quantitative method to predict the probability of one-,three-and five-year survival time of individuals, we established a prognostic nomogram that integrates clinical pathology independent risk factors with a prognostic model (Fig. 4F). The gene discussed is PKIA; the disease is lung cancer.