ITGB2 and rheumatoid arthritis: As depicted from Fig. 1, a significant upregulation in serum ITGB2 mRNA expression was recorded in RA and OA patients in comparison with healthy controls with a median (IQR) fold change of 18.04 (6.979–24.99), P < 0.0001 and 4.8 (1.641–15.56), P = 0.01, respectively.