Zhigang Zhang group reported that Multi-walled carbon nanotube (MWCNT)-induced lung fibrosis facilitated lung myofibroblasts differentiation in an ADORA2B-dependent manner, and the ADORA2B antagonist CVT-6883 significantly reduced the lung fibrosis degree in MWCNT-treated mice [20]. This evidence concerns the gene ADORA2B and pulmonary fibrosis.