In addition, we also conducted a Bleomycin-induced lung fibrosis mice model and from day 8th mice were intraperitoneally injected Dex or PBS of equal volume continuously for 7 days as shown in Fig. 1A. Immunofluorescence staining revealed that compared with the Control group, Bleomycin strongly induced the phosphorylation of p-ERK, p-JNK and p-p38 in lungs. The gene discussed is MAPK8; the disease is pulmonary fibrosis.