In addition, these 20 patients with LGI1 encephalitis were classified into three subgroups: 6 patients with anti-LGI1 antibody only in serum, 3 with anti-LGI1 antibody only in CSF, and 11 patients with anti-LGI1 antibody in serum and CSF. This evidence concerns the gene LGI1 and encephalitis.