Our previous study demonstrated that Qijing Mingmu decoction (QJMM) drug serum could significantly suppress the expression of MMP1, MMP3 and TIMP1, and increase the expression of TIMP3 and TGS-6 in CCH fibroblasts, indicating the effectiveness of QJMM drug serum for the therapy of CCH [23, 24]. The gene discussed is TIMP1; the disease is columnar cell hyperplasia of the breast.