Relevant molecules in the tumor microenvironment including granulocyte colony-stimulating factor (G-CSF) and transforming growth factor-β (TGF-β) induce an increased secretion of ARG1, ROS, NO, PGE2 by neutrophils, thereby inhibiting the activation of CD8 + T cells and NK cells [16]. Here, TGFB1 is linked to neoplasm.