Considering the wide hypoconnectivity within cortical-subcortical-cerebellar regions in schizophrenia [23] and the evidence that SAP97 can enhance AMPAR responses in the low activity state of prefrontal neurons [24], we speculate that the change in SAP97 protein structure caused by the T > A variation in the rs3915512 polymorphism [7] with higher RSFC fails to have such an enhanced function [25]. Here, DLG1 is linked to schizophrenia.