BRCA1 and pancreatic neoplasm: In a large case–control study comparing 3030 patients with pancreatic cancer with reference controls, significant associations were observed between pancreatic cancer and BRCA2 [1.9% of cases and 0.3% of controls; odds ratio (OR), 6.20; 95% confidence interval (CI), 4.62–8.17] and BRCA1 (0.6% of cases and 0.2% of controls; OR, 2.58; 95% CI, 1.54–4.05) mutations [15].