BRCA1 and colorectal carcinoma: Contrarily, a retrospective study in five countries from Canada, the United States or Europe reported that the incidence of CRC in BRCA1 (standardised incidence ratio (SIR), 0.92; 95% CI, 0.54–1.40, P = 0.7) and BRCA2 (SIR, 0.82; 95% CI, 0.30–1.81, P = 0.7) mutation carriers was not greater as compared to that of the general population [16].