Another study analysed the coding regions of 27 cancer-predisposing genes in 12,503 unselected Japanese CRC patients and 23,705 controls by using target sequencing and a genome-wide SNP chip, which identified that the pathogenic variants of BRCA1 (OR, 2.6) and BRCA2 (OR, 1.9) were significantly associated with CRC development [20]. This evidence concerns the gene BRCA1 and cancer.