DES and familial dilated cardiomyopathy: However, compared to non-failing and compensated hypertrophic hearts, upregulation of desmin and some low molecular weight bands that are prone to misfolding, aggregation, and cleavage (Agnetti et al. 2014) were detected in biopsies of not only HCM, but also DCM and ISHD patients with HF (Chen et al. 2018).