By cross-linking with microtubules in a detyrosination-dependent manner (Gurland and Gundersen 1995; Liao and Gundersen 1998), desmin was reported to be increased in heart failure (HF) patients and using septal myectomy samples of HCM patients (Chen et al. 2018; Schuldt et al. 2021). This evidence concerns the gene DES and hydrops fetalis.