IGF2BP3 and colorectal carcinoma: Taken together, hsa_circ_0074854 exerts its effects by suppressing miR-2110, leading to the upregulation of ENO2/IGF2BP3, which in turn promotes colorectal cancer (CRC) cell proliferation, migration, invasion, and cell cycle progression, while inhibiting CRC cell apoptosis, and is accompanied by immune cell infiltration (Fig. 9).