Taken together, hsa_circ_0074854 exerts its effects by suppressing miR-2110, leading to the upregulation of ENO2/IGF2BP3, which in turn promotes colorectal cancer (CRC) cell proliferation, migration, invasion, and cell cycle progression, while inhibiting CRC cell apoptosis, and is accompanied by immune cell infiltration (Fig. 9). This evidence concerns the gene IGF2BP3 and colorectal cancer.