FBXO7 and neurodegenerative disease: Furthermore, three novel pathogenic FBXO7/PARK15 mutations in two families were recently reported, showing unambiguously that recessive mutations in the gene encoding the F-box protein 7,FBXO7 (Randle and Laman 2017; Joseph et al. 2019; Zhong et al. 2022; Deng et al. 2013) cause a neurodegenerative disease with early onset, parkinsonian–pyramidal phenotype (Di Fonzo et al. 2009).