Recently, two separate findings provided significant support to the existence of a functional relation between Skp1 and brain degeneration in mammals: (1) The identification of parkinsonism-causing mutations in PARK15/FBXO7 (Di Fonzo et al. 2009; Randle and Laman 2017; Wang et al. 2021), a Skp1-interacting protein belonging to the family subgroup of F-box domain only (Fbxo) proteins (Dabool et al. 2020). This evidence concerns the gene FBXO7 and Parkinson disease.