TH and Parkinson disease: Consistent with this is the accumulation of a wide spectrum of ubiquitinated protein aggregates in brains of PD patients, such as tyrosine hydroxylase (TH), synphilin-1, α-synuclein, and phosphorylated tau (Liani et al. 2004; Meredith et al. 2004; Zhang and Goodlett 2004), which constitutes the most common form of the idiopathic and genetic disease.