MAPT and Parkinson disease: In addition to SKP1A decline, which may cause evasion of proteins subjected to SCF/26S proteasome complex degradation, the reduction in the expression of HSPA8 (coding for Hsc-70), responsible for recognizing unfolded or aberrant proteins, may exacerbate the accumulation of a wide spectrum of ubiquitinated protein aggregates in PD brains such as TH, synphilin-1, α-synuclein, and phosphorylated tau (Murata et al. 2003; Imai et al. 2002; Dabool et al. 2020; Deng et al. 2013).