SFRP1, serving as a small-molecule signal derived from the RPE, elevated the levels of Ca2+ and p-CaMKII, the 2 key molecules in the noncanonical Wnt signaling pathway, in the endothelial cells of the choriocapillaris and choroidal vessels (Fig. 5h, i, k) and caused dysfunction of the endothelial cells, such as promoted apoptosis, suppressed aggregation, and enhanced migration (Fig. 5c–g), leading to reduced choroidal blood perfusion and diminished choroidal vessel lumen area in the FDM model (Fig. 6e–j), and eventually to the occurrence of nonpathologic myopia. The gene discussed is SFRP1; the disease is myopia.