The results showed similar intergroup trends of the lumen areas of choroidal vessels to those revealed by OCTA (both P < 0.001, NOR vs FDM at 1 w and 6 w; P = 0.054, FDM vs shRNA at 1 w; all P < 0.001, FDM vs shRNA at 6 w, FDM vs WAY at 1 w and 6 w; P < 0.05, shRNA vs Scr at 1 w; P < 0.01, WAY vs DMSO at 1 w; both P < 0.001, shRNA vs Scr at 6 w, WAY vs DMSO at 6 w; Fig. 6j, k), providing an anatomical basis for the changes in choroidal circulation when targeting cochlin and SFRP1 for early intervention of nonpathologic myopia. This evidence concerns the gene SFRP1 and myopia.