A DCIS (HER2 positive, hormone receptor positive) with BI-RADS 4a category by standard breast US showed false-negative 2D SWE (Emean < 90 kPa) and true-positive 2D + 3D SWE (Emean > 90 kPa) (Fig. 5). This evidence concerns the gene NR4A1 and ductal breast carcinoma in situ.