PI3K/AKT signaling pathway is closely related to pathway in cancer, apoptosis, MAPK signaling pathway, and FOX signaling pathway, and is involved in malignant biological behaviors such as tumor proliferation, apoptosis, and metastasis, suggesting that SAL may play an anti-EC role through PI3K/AKT signaling pathway26,27 (Fig. 5). Here, AKT1 is linked to cancer.