The signaling pathways in which SAL exerted anti-EC were found to include the pathway in cancer, PI3K-AKT signal pathway, apoptosis, MAPK signal pathway, FOX signal pathway etc. AKT1, CASP3, EGFR, HIF1A, and MMP9 were significantly enriched in PI3K/AKT signaling pathway, pathway in cancer, apoptosis, MAPK signaling pathway, and FOX signaling pathway. This evidence concerns the gene HIF1A and cancer.