HIF1A and gastric cancer: In summary, our study provided the first evidence (Fig. 6g) that the loss of NDUFS1 expression in GC cells was conducive to the activation of mROS-HIF1α signaling pathway and the induction of transcriptional expression of HIF1α downstream genes such as GLUT1, VEGFA, and FBLN5, which are responsible for the malignant progression of GC.