By analyzing the immune characteristics of CAPs, we found significant differences for 11 immune cells (activated B cells, memory B cells, gamma-delta T cells, natural killer T cells, activated CD8 + T cells, central memory CD8 + T cells, effector memory CD8 + T cells, effector memory CD4 + T cells, natural killer cells, eosinophils, and monocytes) between the CAPs and control groups, thus suggesting that innate and adaptive immune systems play a pivotal role in driving chronic inflammation associated with CAPs in the arterial wall. Here, CD4 is linked to cryopyrin-associated periodic syndrome.