In summary, we identified 7 immuno-related differential genes between CAPs and normal carotid artery samples for the first time, which included BTK, LYN, PTPN11, CD163, CD4, ITGAL, and ITGB7; this finding might be instrumental in understanding the process of CAPs and serve as potential targets of immunotherapy. Here, ITGB7 is linked to cryopyrin-associated periodic syndrome.