By using integrated bioinformatics methods, 11 significantly different types of immune cells were identified between the CAPs and control groups, and 7 hub genes (BTK, LYN, PTPN11, CD163, CD4, ITGAL, and ITGB7) may serve as potential biomarkers to differentiate between CAPs and control samples. Here, BTK is linked to cryopyrin-associated periodic syndrome.