Our study found that SCARB1 in NPC-derived EVs could regulate CYP1B1 through the transcription factor KLF9 and inhibit phagocytosis of M2 macrophages, thus promoting NPC metastasis, and we will further explore the signaling pathways that play a role in this process in the future. Here, CYP1B1 is linked to nasopharyngeal carcinoma.