We characterized the expression level of SCARB1 in NPC and its relationship with prognosis by tissue microarray, and subsequent experiments demonstrated that SCARB1 promoted metastasis through the regulation of HAAO in M1 macrophages and CYP1B1 in M2 macrophages by the transcription factor KLF9, respectively. Here, SCARB1 is linked to nasopharyngeal carcinoma.