PPP2CA and metastatic prostate carcinoma: Importantly, 7C10-C5 staining of a localized and metastatic prostate cancer TMA revealed a complete loss of PP2A-C carboxymethylation specifically in metastatic prostate cancer cells and as expected a more heterogenous pattern of staining noted in localized prostate cancer specimens (Fig. 1e, Supplementary Fig. 2g).