Furthermore, the behavioral tests showed that conditional overexpression of NRBF2 in aNSCs significantly increased the social interaction ratio and decreased immobility time in TST and FST of CSDS-exposed mice compared with that of the control group (Fig. 8b), suggesting that conditional overexpression of NRBF2 in the DG aNSCs ameliorates CSDS-induced depression-like behavior. Here, NRBF2 is linked to depressive disorder.