Activation of PPARα and PPARβ/δ with elafibranor induced the hepatic expression of genes that regulates fatty acid β-oxidation including, Acyl-CoA dehydrogenase medium chain (Acadm) and Acyl-CoA oxidase 1 (Acox1) and potently reduced glycoprotein NMB (Gpnmb) expression on KCs, which was closely associated with liver injury and fibrosis in a cohort of mice with varying degrees of NASH severity [83]. Here, ACADM is linked to metabolic dysfunction-associated steatohepatitis.