Hepatic macrophages play crucial roles both in the maintenance of hepatic homeostasis and in the molecular mechanisms underlying liver disease [17, 18], and these functions involve the p53 network [19–27] or non-coding RNA [28–31] Indeed, the heterogeneity of hepatic macrophages and involvement of different subsets of macrophages are crucial to the pathogenesis of liver diseases (Supplementary Table 1). Here, TP53 is linked to liver disorder.