Previous studies have shown that PIK3AP1, a therapeutic target, inhibits the occurrence and development of gastric cancer [24], thyroid cancer [25], cervical cancer [26, 27], and others by regulating the PI3K/Akt signaling pathway indicating that PIK3AP1 plays a key role in PI3K/Akt signaling. This evidence concerns the gene PIK3AP1 and thyroid gland carcinoma.