Targeting the METTL3-Ythdc2-LRP2 axis to regulate neurogenesis may be a promising antidepressant strategy.356 Evidence from other studies suggests that upregulated METTL3 can aggravate cognitive impairment in rats exposed to CUMS by mediating m6A modification to promote the processing and maturation of pri-miR-221. The gene discussed is METTL3; the disease is Cognitive impairment.