Blocking SIRT1 function in the hippocampus increases depression-like behaviors.151 SIRT1 is also one of the first genes (SNPs; rs12413112) identified using GWAS to be associated with MDD.154,155 Furthermore, lower SIRT expression levels in peripheral blood samples of MDD patients156 align with findings from other studies.157 Taken together, these findings suggest that activating SIRT1-dependent pathways may be a potential therapeutic strategy for MDD. This evidence concerns the gene SIRT1 and major depressive disorder.