The FTO variant rs9939609 in human trials was associated with a lower risk of developing MDD.358 A correlation is reported between FTO variants and the severity of MDD.359 Lack of the FTO gene impacts anxiety-depression-like behavior in mice.360 Adrenoceptor 2 (Adrb2) mRNA appears to be a target of FTO. This evidence concerns the gene ADRB2 and major depressive disorder.