Sole mutations in KRAS, which do not arise in the context of prior WNT-activating mutations are exceedingly rare in adenomas, and in a murine model, a single Kras mutation resulted in senescence as opposed to hyperproliferation seen in the Apc-Kras mutational sequence (Bennecke et al, 2010; Feng et al, 2011; Smit et al, 2020). Here, APC is linked to adenoma.