Hence, we evaluated the role of FAM76B in the common neurodegenerative diseases Alzheimer’s disease (AD), frontotemporal lobar degeneration with tau pathology (FTLD-tau), and frontotemporal lobar degeneration with TAR DNA-binding protein 43 inclusions (FTLD-TDP). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.