NFE2L2 and liver cancer: For instance, Tripartite motif containing 25 (TRIM25) is the most important induced gene in response to ER stress, and ER stress leads to the increase of TRIM25, which promotes the development of liver cancer through the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) signalling pathway[3].