HLA-DRB1 and Alzheimer disease: This PHF6/HLA-DRB4*01 strong binding was confirmed in vitro (SI Appendix, Fig. S10), but the absence of AD or PD association with HLA-DRB1*07:01 and HLA-DRB1*09:01, whose haplotypes are in linkage with HLA-DRB4*01, ruled out its involvement (SI Appendix, Table S14).