DARS1 and infection: Moreover, the distribution of DARs on functional genomic elements revealed that promoter-TSS and intergenic regions are also preferentially accessible to Tn5 transposase (Fig 1C), with a relatively large number of promoter-TSS regions exhibiting significantly different accessibility, hinting that most DARs resulting from infection may represent proximal regulatory elements, such as promoters, located close to the genes they control, favoring gene transcription.