CFTR and intestinal cancer: Previous studies in MYO5B-knockout animal models and intestinal cancer cell lines have shown profound loss or mislocalization of key transporters such as the intestinal sodium-dependent glucose cotransporter (SGLT1) and sodium/hydrogen exchanger 3 (NHE3) from the apical membrane, with intact cystic fibrosis transmembrane conductance regulator (CFTR) localization (16).