GSEA revealed that, compared with KC mice, KSC mice had an enrichment in stem cell networks (ESC pluripotency, Wnt, Notch, Hedgehog); EMT; a pancreatic ductal cell program; cancer-associated networks; and EGFR, ERBB2/HER2, and MET signaling pathways (Figure 3F and Supplemental Table 2). This evidence concerns the gene ERBB2 and keratoconus.