Studies focused on the profibrotic role of PGDF in IPF have shown that inhibiting PDGF-BB signaling with Imatinib (a tyrosine kinase inhibitor of PDGFR) or APB5 (a PDGFR-β blocking antibody) attenuates bleomycin-induced PF (50, 51). This evidence concerns the gene PDGFRB and idiopathic pulmonary fibrosis.