To investigate whether platelet-derived TGFβ1 has a direct profibrotic role in IPF, a conditional knockout transgenic mouse, in which TGFβ1 is deleted in megakaryocytes and subsequent platelets (TGFβ1fl/fl.PF4-Cre) (29) was used in the bleomycin-induced PF model. The gene discussed is TGFB1; the disease is idiopathic interstitial pneumonia.