Notably, analysis of our m6Am-Seq data identified 2 m6Am sites in the 5′-UTRs of TET2 transcript in both PCIF1 KO and CTBP2 KO (Figure 4, H and I), suggesting that TET2 might be a downstream target of PCIF1 and CTBP2 in HNSCC. The gene discussed is TET2; the disease is head and neck squamous cell carcinoma.