Importantly, a high CTBP2 protein level was significantly correlated with high tumor stage and tumor grade in cohort 1 (Supplemental Figure 3, D–G), whereas a high CTBP2 protein level was significantly correlated with T classification, tumor stage, and lymph node metastasis status in cohort 2 (Supplemental Figure 3, K–N). Here, CTBP2 is linked to neoplasm.