NLRP1 and asthma: In addition, rare germline mutations and single-nucleotide polymorphisms in NLRP1 are associated with infection sensitivity, skin, corneal, and intestinal inflammatory disorders as well as with asthma susceptibility in humans, hence underlying an important function of NLRP1 at triggering an innate immune response in various epithelia (Zhong et al., 2016; Griswold et al., 2022).