Resistance to mTORi has previously been investigated in several cancer types, and MYC has been reported as a resistance mechanism (Allen-Petersen et al., 2019; Ilic et al., 2011; Matsumoto et al., 2015; Muellner et al., 2011; Muranen et al., 2016; Shepherd et al., 2013; Song et al., 2021; Tan et al., 2013; Dey et al., 2014). The gene discussed is MYC; the disease is cancer.