In the exploration of large sample data in the TCGA database, CDC45 was found to be a key tumor-associated gene in cervical cancer (Zhang and Zhao 2016), prostate cancer (Li et al. 2017) and lung cancer (Zhang et al. 2014), and the analysis of prognostic correlation showed that CDC45 was significantly related to poor prognosis in non-small cell lung cancer (Piao et al. 2018) and pancreatic cancer (Haider et al. 2014). Here, CDC45 is linked to Familial prostate cancer.