Quantification of IHC results revealed that positive nuclear staining of FOSL1 was significantly higher in grade II (n = 51, p < 0.05), grade III (n = 12, p < 0.05), grade IV GBM (n = 12, p < 0.0001) compared with that of normal brain tissue (n = 10) (Fig. 7F). This evidence concerns the gene FOSL1 and glioblastoma.