TRPM7 and central nervous system cancer: Quantification of the IHC results revealed that positive cytoplasmic staining of TRPM7 was significantly higher in grade II (n = 51, p < 0.01), grade III (n = 12, p < 0.001), grade IV GBM (n = 12, p < 0.0001) compared with that of normal brain tissue (n = 10) (Fig. 7B left); positive nuclear staining of TRPM7 in grade III gliomas (p < 0.05) and grade IV (p < 0.01) was significantly higher than that of normal brain tissue (Fig. 7B right).