Given the importance of the − 328 to − 336 and − 378 to − 386 GAS elements in the activation of FOSL1 promoter in glioma cells, we sought to examine whether cotransfection of a constitutively active mutant of STAT3 or a dominant negative mutant of STAT3 along with the FOSL1 promoter could enhance or suppress FOSL1 promoter activity. The gene discussed is STAT3; the disease is central nervous system cancer.