The major findings include: (1) FOSL1 downregulation suppresses glioma stemness/tumor cell growth and decreases the expression of GSC markers CD133 and ALDH1; (2) mechanistically, TRPM7 induces STAT3-mediated FOSL1 transcriptional activation during gliomagenesis; (3) clinico-pathologically, the TRPM7 protein expression correlates to the protein expression of ALDH1 and FOSL1 and is associated with grades of malignant glioma. Here, FOSL1 is linked to central nervous system cancer.