The major findings include: (1) FOSL1 downregulation suppresses glioma stemness/tumor cell growth and decreases the expression of GSC markers CD133 and ALDH1; (2) mechanistically, TRPM7 induces STAT3-mediated FOSL1 transcriptional activation during gliomagenesis; (3) clinico-pathologically, the TRPM7 protein expression correlates to the protein expression of ALDH1 and FOSL1 and is associated with grades of malignant glioma. This evidence concerns the gene TRPM7 and central nervous system cancer.