In this research project, we comprehensively analyzed the relationship between the expression of CAV1 and glioma patients’ survival, the immune cell infiltration features, the CAV1 methylation status and its functions in glioma progression and cancer cells’ OXPHOS inhibition based on different databases, either from public resources or our own RNA-sequencing and WGBS sequencing. The gene discussed is CAV1; the disease is central nervous system cancer.