To further verify the hypothesis, we checked the expression of CAV1 and the key OXPHOS pathway genes including MT-CO1, MT-CO2 and MT-CO3, and found that the expression of CAV1 is negatively related to the expression of MT-CO1, MT-CO2 and MT-CO3 in LGG and GBMLGG (Fig. 7I–K), but the correlations between CAV1 and OXPHOS genes in GBM is not as strong as that in LGG and GBMLGG. The gene discussed is CAV1; the disease is glioblastoma.