According to our analysis of the OXPHOS-inhibition resistant and OXPHOS-inhibition sensitive cancer cells [12], we found the scaffolding protein encoded by Caveolin-1(CAV1) is highly expressed in the OXPHOS-inhibition resistant cells lines, thus we postulate that CAV1 may function in glioma and contributes to its resistance to OXPHOS inhibition. The gene discussed is CAV1; the disease is glioma.