MT-CO3 and glioblastoma: To further verify the hypothesis, we checked the expression of CAV1 and the key OXPHOS pathway genes including MT-CO1, MT-CO2 and MT-CO3, and found that the expression of CAV1 is negatively related to the expression of MT-CO1, MT-CO2 and MT-CO3 in LGG and GBMLGG (Fig. 7I–K), but the correlations between CAV1 and OXPHOS genes in GBM is not as strong as that in LGG and GBMLGG.