To check whether CAV1 is the essential gene for all glioma cancer cell’s viability, we mined the DepMap data for the whole-genome CRISPR knocking out CAV1 in 67 glioma cancer cell lines and found the CERES scores of 45 cell lines are above zero and 22 cell lines are below zero (Supplementary Table 5), indicating that CAV1 are essential for some of the glioma cells not for all and there is high heterogeneity of gliomas. Here, CAV1 is linked to central nervous system cancer.